Triazabicyclodecene: An Effective Isotope Exchange Catalyst in CDCl_3

摘要

We describe the first effective H/D exchange reaction with acidic substrates in CDCl_3 at room temperature. The particularly mild reaction conditions involved (solvent, base, and temperature) allow the chemoselective deuteration of ketones over esters. An NMR study was conducted with the aim of rationalizing the results obtained in the presence of TBD as catalyst.