Correlation between androgen receptor expression and FGF8 mRNA levels is patients with prostate cancer and benign prostatic hypertrophy

摘要

Aim-To investigate the correlation be- tween androgen receptor expression and fibroblast growth factor 8 (FGF8) mRNA levels. Methods-39 human prostate cancers and 14 benign prostatic hypertrophy speci- mens were examined immunohistochemi- cally for androgen receptor expression and by in situ hybridisation and reverse transcription polymerase chain reaction for FGF8 expression Results-In 39 tumours there was a statis- Tically significant negative correlation be- Tween tumour grade and FGF8 expression And a positive correlation between FGF8 And androgen receptor expression.