Stereospecific Alkenylation of C-H Bonds via Reaction with β -Heteroatom-Functionalized Trisubstituted Vinyl Triflones

摘要

Aryl and alkyl β-heteroatom-trisubstituted vinyl triflones react with THF and cyclohexane to undergo trifluoromethyl radical-mediated C-H functionalization reactions to afford E and Z β-heteroatom-trisubstituted olefins. Most reactions proceed with both high yield and high stereospecificity (retention of configuration). β-Substituents which have been employed in this study are iodine, bromine, fluorine, benzoate, ethylcarbonate, and phthalimide.