A Hybrid PET-MRI: An Integrated Molecular-Genetic Imaging System with HRRT-PET and 7.0-T MRI

摘要

A PET-MRI fusion system is developed for molecular-genetic imaging. The purpose of the system is to obtain images of the in-vivo human brain using two high-end imaging devices, an advanced PET and an ultrahigh-field MRI. These are the HRRT-PET, a high-resolution research tomograph dedicated to brain imaging on the molecular level, and the 7.0-T MRI, an ultrahigh field version used for morphological imaging. HRRT-PET delivers high-resolution molecular imaging with a resolution down to 2.5 mm FWHM, which is currently the highest spatial resolution available for the observation of the human brain's molecular activities, including enzymes and receptors, which are manipulated genetically, such as reporter genes and probes. The 7.0-T MRI began to reveal submillimeter resolution images of the cortical as well as deep brain areas, down to 250 urn, which allows us to visualize the fine details of the cortical and brainstem areas, including the line of Gennari in the visual cortex and the corticospinal tracts in the pontine area. The current PET-MRI fusion imaging system produces the highest quality images of molecular and genetic activities of the human brain in vivo. It is starting to provide many answers to the key questions about the neurological diseases. Some of these start providing answers to many cognitive neuroscience problems with clear molecular and genetic bases. There is great potential in the PET-MRI for early diagnosis of cancers as well as other neurological diseases, which we were previously unable to diagnose, such as microscopic molecular changes that occur in Parkinson's and Alzheimer's diseases.