DOSE-AND TIME-DEPENDENT FORMATION OF BILIARY BANZO[a]PYRENE METABOLITES IN THE MARINE FLATFISH(LIMANDA LIMANDA)

摘要

Polycyclic aromatic hydrocarbns(PAHs)are abundant pollutants, and many PAHs are carcinogenic, but only after metabolic activation. Bnezo[a]pyrene (BaP)is among the most carcinogenic PAHs. The dose and time response of two enzymes involved in BaP metabolism and the amounts of BaP metabolites excreted into the bile were evaluated in an experiment with dab (Limanda limanda). Ninety dab were exposed orally to one of five doses of BaP(0, 0.08, 0.4, 2, or 10 mg/kg)and sampled at 3, 6, or 12 d after exposure.