Response to the Comment on 'Partitioning of polar and non-polar neutral organic chemicals into human and cow milk'

摘要

Rayne (Rayne, 2013) pointed out that one compound (N,N-diethylaniline) out of the 96 calibration compounds that we used in the previous study (Geisler et al., 2011) may be present significantly in its protonated form in the aqueous phase of milk and should be removed from consideration. Assuming that the experimental pk_a value he cited is accurate, his claim is correct Removing N,N-diethylaniline from the data set and using the remaining 95 calibration compounds, we have recalculated the polyparameter linear free energy relationship (pp-LFER) equations.