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首页> 外文期刊>Diabetes >Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart
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Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

机译:营养应激通过抑制心脏中的AMP激活的蛋白激酶来激活炎症并减少葡萄糖代谢

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摘要

Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a role of inflammation in peripheral insulin resistance, but the impact of inflammation on cardiac metabolism is unknown. We investigated the effects of diet-induced obesity on cardiac inflammation and glucose metabolism in mice.
机译:心力衰竭是糖尿病死亡的主要原因,可能与代谢改变有因果关系。最近的报道表明炎症在外周胰岛素抵抗中的作用,但是炎症对心脏代谢的影响尚不清楚。我们调查了饮食引起的肥胖对小鼠心脏炎症和葡萄糖代谢的影响。

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  • 来源
    《Diabetes》 |2009年第11期|p.2536-2546|共11页
  • 作者单位

    Hwi Jin Ko,1,2 Zhiyou Zhang,2 Dae Young Jung,1,2 John Y. Jun,2,3 Zhexi Ma,2 Kelly E. Jones,2 Sook Y. Chan,2 and Jason K. Kim1,2,4From the 1 Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, the 2 Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, the 3 Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, and the 4 Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts.Corresponding author: Jason K. Kim, jason.kim@umassmed.edu.Received 3 October 2008 and accepted 2 August 2000. Published ahead of print at http://diabetes.diabetesjounials.org on 18 August 2009. DOI: 10:2337/db08-1361.H.J.K. and Z.Z. contributed equally to this article and should be considered co-first authors.© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativetcommons.org/licenses/by-nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1784 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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