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首页> 外文期刊>Diabetes >Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4
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Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

机译：胰高血糖素样肽-1受体激动剂Exendin-4抑制单核细胞对内皮细胞的粘附并减轻动脉粥样硬化病变。

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摘要

Exogenous administration of glucagon-like peptide-1 (GLP-1) or GLP-1 receptor agonists such as an exendin-4 has direct beneficial effects on the cardiovascular system. However, their effects on atherosclerogenesis have not been elucidated. The aim of this study was to investigate the effects of GLP-1 on accumulation of monocytes/macrophages on the vascular wall, one of the earliest steps in atherosclerogenesis.
机译：胰高血糖素样肽1（GLP-1）或GLP-1受体激动剂（例如exendin-4）的外源给药对心血管系统具有直接的有益作用。然而，尚未阐明它们对动脉粥样硬化的作用。这项研究的目的是研究GLP-1对血管壁单核细胞/巨噬细胞积累的影响，这是动脉粥样硬化发生的最早步骤之一。

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  • 来源
    《Diabetes》 |2010年第4期|p.1030-1037|共8页
  • 作者

    Masayuki Arakawa Tomoya Mita Kosuke Azuma Chie Ebato Hiromasa Goto Takashi Nomiyama Yoshio Fujitani Takahisa Hirose Ryuzo Kawamori Hirotaka Watada;

  • 作者单位

    Masayuki Arakawa,1 Tomoya Mita,1 Kosuke Azuma,1 Chie Ebato,1 Hiromasa Goto,1 Takashi Nomiyama,1 Yoshio Fujitani,1,2 Takahisa Hirose,1,2 Ryuzo Kawamori,1-4 and Hirotaka Watada1,3From the 1 Department of Medicine, Metabolism and Endocrinology, Jun tendo University Graduate School of Medicine, Tokyo, Japan, the 2 Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan, the 3 Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, and the 4 Center for Beta Cell Biology and Regeneration, Juntendo University Graduate School of Medicine, Tokyo, Japan.Corresponding author: Tomoya Mita, tom-m@juntendo.acjp, or Hirotaka Watada, hwatada@med.juntendo.ac.jp.Received 17 November 2009 and accepted 28 December 2009. Published ahead of print at http://diabetes.diabetesjournals.org on 12 January 2010. DOI: 10.2337/db09-1694.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article mvst therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1794 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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