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Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

机译：Lipocalin-2缺乏症可减轻与衰老和肥胖相关的胰岛素抵抗

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摘要

The proinflammatory cytokines/adipokines produced from adipose tissue act in an autocrine and/or endocrine manner to perpetuate local inflammation and to induce peripheral insulin resistance. The present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on systemic insulin sensitivity and the underlying mechanisms.
机译：由脂肪组织产生的促炎细胞因子/脂肪因子以自分泌和/或内分泌的方式起作用，以维持局部炎症并诱导外周胰岛素抵抗。本研究调查脂蛋白2缺乏或补充该脂肪因子是否对全身胰岛素敏感性及其潜在机制有影响。

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  • 来源
    《Diabetes》 |2010年第4期|p.872-882|共11页
  • 作者

    Ivy K M Law Aimin Xu Karen S L Lam Thorsten Berger Tak W Mak Paul M Vanhoutte Jacky T C Liu Gary Sweeney Mingyan Zhou Bo Yang Yu Wang;

  • 作者单位

    Ivy K.M. Law,1 Aimin Xu,1'2 Karen S.L. Lam,2 Thorsten Berger,3 Tak W. Mak,3 Paul M. Vanhoutte,1 Jacky T.C. Liu,1 Gary Sweeney,4 Mingyan Zhou,1'2 Bo Yang,1 and Yu Wang1,2From the 'Department of Pharmacology and Pharmacy, the University of Hong Kong, Hong Kong, China, the 2Department of Medicine and Research Center of Heart, Brain, Hormone, and Healthy Aging, the University of Hong Kong, Hong Kong, China, 3TlIe Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Ontario, Canada, and the 4 Department of Biology, York University, Toronto, Ontario, Canada.Corresponding author Yu Wang, yuwanghk@hku.hk.Received 16 October 2009 and accepted 20 December 2009. Published ahead of print at http://diabetes.diabetesjournals.org on 12 January 2010. DOI: 10.2337/db09-1541.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by Ote payment of page charges. 7his article mttst therefore be hereby marked "advertisement" in accordance with i8 U.S.C. Sectimi 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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