Albuminuria in Patients With Type 1 Diabetes Is Directly Linked to Changes in the Lysosome-Mediated Degradation of Albumin During Renal Passage

摘要

Previous studies by our group have shown that albumin is metabolized in rodents during renal passage and excreted in the urine as a mixture of intact protein and albumin-derived fragments. The aim of this study was to examine whether albumin is metabolized during renal passage in nondiabetic volunteers and in type 1 diabetic patients with varying levels of albuminuria. Nine nondi- abetic patients with albumin excretion rates varying from normoalbuminuria to macroalbuminuria were studied.