Ginkgo paste improves tinea corporis in a guinea pig model

摘要

To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model. The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains. And then, high and low doses of Ginkgo water-paste and alcohol-paste were administrated to the animals. The symptom, tinea corporis skin lesions and histopathological aspects of guinea pig were analyzed. High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste could significantly reduced the tinea corporis symptom ( P 0.01), increased negative rate of strain culture ( P 0.01), and improved pathological changes of tinea corporis ( P 0.01). The best efficacy was observed in high dose ginkgo alcohol paste group. These results suggest that Ginkgo paste exhibits the efficacy to treat tinea corporis in a guinea pig model.