Breakthrough Candida krusei Fungemia during Fluconazole Prophylaxis followed by Breakthrough Zygomycosis during Caspofungin Therapy in a Patient with Severe Aplastic Anemia Who Underwent Stem Cell Transplantation

Corrado Girmenia; Maria Luisa Moleti; Alessandra Micozzi; Anna Paola Iori; Walter Barberi; Robin Foà; Pietro Martino

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Breakthrough Candida krusei Fungemia during Fluconazole Prophylaxis followed by Breakthrough Zygomycosis during Caspofungin Therapy in a Patient with Severe Aplastic Anemia Who Underwent Stem Cell Transplantation

机译：严重再生障碍性贫血患者接受干细胞移植的氟康唑预防期间突破性克鲁斯念珠菌病，卡泊芬净治疗期间突破性合子菌病

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We report a case of breakthrough invasive zygomycosis in a stem cell transplant recipient who was receiving caspofungin for treatment of a breakthrough Candida krusei fungemia that occurred during fluconazole prophylaxis. Also, patients receiving the echinocandin caspofungin remain at risk for pathogens, such as zygomycetes, that are intrinsically resistant to this agent.

机译：我们报道了一例在接受卡泊芬净治疗氟康唑预防期间发生的突破性 Candida krusei 真菌病的干细胞移植受者中突破性侵袭性真菌病的病例。同样，接受棘皮菌素卡泊芬净的患者仍然存在固有病原体（例如合子菌）对该病原体耐药的风险。 展开▼

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《Journal of Clinical Microbiology》 |2005年第10期|共2页

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Corrado Girmenia; Maria Luisa Moleti; Alessandra Micozzi; Anna Paola Iori; Walter Barberi; Robin Foà; Pietro Martino;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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1. Candida glabrata and Candida krusei fungemia after high-risk allogeneic marrow transplantation: no adverse effect of low-dose fluconazole prophylaxis on incidence and outcome. [J] . Safdar A, van-Rhee F, Henslee-Downey JP, Bone marrow transplantation . 2001,第9期

机译：高危同种异体骨髓移植后的光滑念珠菌和克鲁斯念珠菌真菌病：低剂量氟康唑预防对发病率和预后无不良影响。

2. Breakthrough Candida guilliermondii Candida guilliermondii ( Meyerozyma guilliermondii Meyerozyma guilliermondii ) fungemia after cord blood transplantation for extranodal NK NK ‐cell lymphoma with azole prophylaxis [J] . Nakazawa Hideyuki, Nishina Sayaka, Senoo Yasushi, Transplant infectious disease: an official journal of the Transplantation Society . 2018,第4期

机译：突破念珠菌念珠菌念珠菌（Meyerozyma Guilliermondii）脐血肠道移植后脐血移植脐血移植与唑类唑类淋巴瘤（Meyerozyma）脐血移植

3. Breakthrough Candida dubliniensis fungemia in an acute myeloid leukemia patient during voriconazole therapy successfully treated with caspofungin. [J] . Fanci R Journal of chemotherapy . 2009,第1期

机译：在伏立康唑治疗过程中，成功用卡泊芬净治疗了急性髓性白血病患者中的突破性假丝酵母念珠菌性真菌病。

4. A severe inflammatory acne was successfully cleared by topical photodynamic therapy mediated with 5-aminolevulinic acid in an refractory aplastic anemia female patient: a case report [C] . Jingyi Huang, Fen Peng, Xiaojing Yang, International Photodynamic Association World Congress;Society of Photo-Optical Instrumentation Engineers;International Photodynamic Association . 2019

机译：通过5-氨基乙酰丙酸介导的局部光动力疗法成功治疗顽固性再生障碍性贫血女性患者严重炎症性痤疮：一例

5. The Effects of Pre-transplant Music Therapy on Distress, Quality of Life, Pain, Anxiety, Mood, and Pain Medication for Patients Undergoing Hematopoietic Stem Cell Transplant [D] . Bates, Deborah S. 2019

机译：移植前的音乐治疗对造血干细胞移植患者的痛苦，生活质量，痛苦，焦虑，情绪和疼痛药物的影响

6. Breakthrough Candida krusei Fungemia during Fluconazole Prophylaxis followed by Breakthrough Zygomycosis during Caspofungin Therapy in a Patient with Severe Aplastic Anemia Who Underwent Stem Cell Transplantation [O] . Corrado Girmenia, Maria Luisa Moleti, Alessandra Micozzi, 2005

机译：严重再生障碍性贫血患者接受干细胞移植的氟康唑预防期间突破性克鲁斯念珠菌病随后卡泊芬净治疗期间突破性合子菌病

7. Breakthrough Candida krusei Fungemia during Fluconazole Prophylaxis followed by Breakthrough Zygomycosis during Caspofungin Therapy in a Patient with Severe Aplastic Anemia Who Underwent Stem Cell Transplantation [O] . Girmenia, Corrado, Moleti, Maria Luisa, Micozzi, Alessandra, 2005

机译：严重再生障碍性贫血患者接受干细胞移植的氟康唑预防期间突破性克鲁斯念珠菌病，随后卡泊芬净治疗期间突破性合子菌病

1. HAART治疗期间口腔念珠菌病的出现提示病人免疫力低下 [J] . 王嘉 . 传染病网络动态 . 2005,第005期

2. 氟康唑预防性治疗急性再生障碍性贫血患者侵袭性真菌病的临床分析 [J] . 戴铁颖 ,沈建平 ,胡致平 . 中国现代应用药学 . 2015,第001期

3. 米克定联合氟康唑治疗严重外阴阴道念珠菌病临床观察 [J] . 刘秀伟 ,刘博伟 . 中国保健营养（中旬刊） . 2012,第0z1期

4. 达克宁栓联合氟康唑治疗严重外阴阴道念珠菌病72例疗效观察 [J] . 李桂玲 . 中国民族民间医药 . 2010,第023期

5. 硝酸咪康唑栓联合氟康唑及硝酸咪康唑软膏治疗严重外阴阴道念珠菌病的临床观察 [J] . 何甫霞 . 中国民康医学 . 2009,第006期

6. 泊沙康唑与氟康唑预防中性粒细胞缺乏患者侵袭性真菌病的药物经济学评价 [C] . . 2017中国临床药学学术年会暨第十三届中国临床药师论坛 . 2017

7. Th17细胞相关细胞因子在HIV/AIDS患者HAART治疗期间变化及其与口腔念珠菌病关系研究 [A] . 雍翔智 . 2015

1. Drugs that encourage the mobilization of hematopoietic stem cells in the bone marrow, including the TAT-HOXB4H protein to the peripheral blood, and medicine in order to improve the hematopoietic stem cell transplant patients, radiation therapy patient or recovery time of chemotherapy patients [P] . 外国专利： JP5738636B2 . 2015-06-24

机译：鼓励动员骨髓中造血干细胞（包括TAT-HOXB4H蛋白）到外周血的药物，以及改善造血干细胞移植患者，放射治疗患者或化疗患者恢复时间的药物

2. OXYGEN OZONE REGENERATIVE THERAPIES WITH ALL INFORMATION ON TREATED PATIENTS; INCLUDED ORGAN TRANSPLANT PATIENTS AND NEW LAB DATA WITH KIDNEY TISSUE CONTAINING STEM CELLS PICTURED GROSSLY IN PATIENT URINE AND STEM AND PROGENITOR CELLS OR CD 34 POSITIVE CELLS PICTURED IN CLUMPS IN URINE [P] . 外国专利： US2019328957A1 . 2019-10-31

机译：具有治疗患者所有信息的氧气臭氧再生疗法;包含肾脏组织的器官移植患者和新实验室数据，其中包含在患者尿液中粗横排列的肾干细胞以及在尿液小结中示出的干细胞和祖细胞或CD 34阳性细胞

3. PHARMACEUTICAL COMPOSITION INCLUDING TAT-HOXB4H PROTEIN FOR ENHANCING MOBILIZATION OF HEMATOPOIETIC STEM CELL FROM BONE MARROW TO PERIPHERAL BLOOD, AND PHARMACEUTICAL COMPOSITION FOR IMPROVING RECOVERY TIME OF PATIENT HAVING UNDERGONE HEMATOPOIETIC STEM CELL TRANSPLANTATION, IRRADIATION, OR CHEMOTHERAPY [P] . 外国专利： JP2011168597A . 2011-09-01

机译：包括Tat-HOXB4H蛋白质的药物组合物，用于增强造血干细胞从骨髓向外周血的移动，以及用于改善患者的治疗，造血干细胞或造血干细胞恢复时间的药物组合物

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Breakthrough Candida krusei Fungemia during Fluconazole Prophylaxis followed by Breakthrough Zygomycosis during Caspofungin Therapy in a Patient with Severe Aplastic Anemia Who Underwent Stem Cell Transplantation

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