Coordinate augmentation in expression of genes encoding transcription factors and liver secretory proteins in hypo-oncotic states

摘要

Coordinate augmentation in the expression of genes encoding transcription factors and liver secretory proteins in hypo-oncotic states.BackgroundIn the nephrotic syndrome (NS) proteins of intermediate size (40 to 200 kD) are lost into the urine resulting in a decrease in plasma albumin concentration and as a consequence a reduction in plasma colloid osmotic pressure (). Plasma has also been reported to be reduced in the condition of hereditary analbuminemia. The liver, in an apparent compensatory response, increases synthesis of a group of secreted proteins defending plasma . Regulation of several of these proteins, including both positive and negative acute phase proteins, is at the transcriptional level. This is the only known condition in which transcription of both positive and negative acute phase proteins (APPs) are increased simultaneously. The specific transcription factor(s) that might regulate this cascade is not defined.