An Efficient and Eco-friendly Approach to 15 N-Unsubstituted ￥a-Lactams: 15 N-Labled Synthons for Taxol and Its Analogs

摘要

An efficient and eco-friendly approach to N-unsubstituted モ-lactams has been developed using mostly water as the reaction medium. This methodology was applied to the synthesis of N-unsubstituted 3-hydroxy-4-phenyl-2-azetidinone derivatives (including 15N-labeled version) which are suitable precursors for the C-13 side chain of taxol and its analogs.