Prognostication of recovery time after acute peripheral facial palsy: a prospective cohort study

摘要

Objective Owing to a lack of prospective studies, our aim was to evaluate diagnostic factors, in particular, motor and non-motor function tests, for prognostication of recovery time in patients with acute facial palsy (AFP). Design Prospective cohort study. Setting University hospital. Participants 259 patients with AFP. Measurements Clinical data, facial grading, electrophysiological motor function tests and other non-motor function tests were assessed for their contribution to recovery time. Results The predominant origin of AFP was idiopathic (59%) and traumatic (21%). At baseline, the House-Brackmann scale (HB) was III in 46% of patients. Follow-up time was 5.6±9.8?months with a complete recovery rate of 49%. The median recovery time was 3.5?months (95% CI 2.2 to 4.7?months). The following variables were associated with faster recovery: Interval between onset of AFP and treatment 6?days versus ≥6?days (median recovery time in months 2.1 vs 6.5; p0.0001); HB ≤III vs III (2.2 vs 4.6; p=0.001); no versus presence of pathological spontaneous activity in first electromyography (EMG; 2.8 vs probability of recovery 50%; p0.0001); no versus voluntary activity in EMG (probability of recovery 50% vs 3.1; p0.0001); normal versus pathological ipsilateral electroneurography (1.9 vs 6.5; p=0.008), normal versus pathological stapedius reflexes (1.6 vs 3.3; p=0.003). Conclusions Start of treatment and grading, but most importantly EMG evaluated for pathological spontaneous activity and the stapedius reflex test are powerful prognosticators for estimating the recovery time from AFP. These results need confirmation in larger datasets.