Application of a 3 3 Box-Behnken Design to Optimize the Extraction of Eleven Fluoroquinolones from Poultry Muscle and Kidney Using a QuEChERS Approach via Liquid Chromatography Tandem Mass Spectrometry: the Easy Use of Microsoft Excel ?? in Multivariate Analysis

摘要

This work presents an optimization of a quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction approach of eleven fluoroquinolones in poultry muscle and kidney using a 3 3 Box-Behnken factorial design. All the data treatment was performed using Microsoft Excel ?? 2010. The suitability of the developed method was confirmed by two proficiency tests for ciprofloxacin and enrofloxacin.