Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats

摘要

Background: Chemotherapy with cisplatin (CP) is accompanied with nephrotoxicity. Objectives: In the current study, pomegranate flower extract (PFE) has been evaluated as an antioxidant agent against CP-induced-renal toxicity. Materials and Methods: Thirty two male Wistar rats were divided into five groups (6-8 in each group). The animals in groups 1 to 3 received PFE (25 mg/kg), PFE (50 mg/kg), and placebo (saline), respectively for 9 days, and onset of the day 3, they also received CP (2.5 mg/kg/ day). Groups 4 and 5 were treated with PFE (25 and 50 mg/kg/day) for 9 days. Finally, the animals were sacrificed at day 9 after collecting blood samples. Kidneys were removed, weighted, and underwent histopathological investigation. Results: The mean serum level of creatinine in group 3 (treated with CP and placebo) increased significantly (p Conclusions: It seems that low dose of PFE plays a protective role against CP-induced renal toxicity in rats