Antiphospholipid Syndrome: A complex disease

摘要

In the last three decades, a variety of clinical manifestations involving almost all organs and tissues (cardiac, pulmonary, neurological, renal, cutaneous, haematologic, gastrointestinal, ocular, skeletal and endocrinologic), have been described associated with antiphospholipid antibodies (aPL) . Nevertheless, the exact mechanism underlying the pathogenesis of aPL-mediated damage has been poorly recognized. Inflammatory mechanisms beyond thrombosis have been proposed in some clinical presentations, suggesting a role for immunomodulation in therapeutic strategy