The evaluation value of the quantitative electroencephalogram for the prognosis of neonatal hypoxic ischemic encephalopathy and its relationship with serological indicators

摘要

Objective: To study the evaluation value of the quantitative electroencephalogram (qEEG)for the prognosis of neonatal hypoxic ischemic encephalopathy (HIE) and its relationshipwith serological indicators. Methods: 76 children with HIE who were born and treated in ourhospital between April 2013 and February 2017 were collected as observation group, and 50healthy newborns who were born in our hospital during the same period were collected asnormal control group. qEEG parameter values of two groups of children were determined,serum levels of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes werecompared between the two groups, and Pearson test was used to evaluate the inner link betweenqEEG parameter values and disease severity in children with HIE. Results: qEEG Fp1, Fp2,C3, C4, T3, T4, O1 and O2 loci power spectrum values of observation group were significantlylower than those of normal control group. Serum NSE, NPY, S-100B and MBP contents inobservation group were higher than those in normal control group; nerve apoptosis indexessFas, sFasL and Caspase-3 contents were higher than those in normal control group whileBcl-2 content was lower than that in normal control group; serum oxidative stress indexesAOPP and MDA contents were higher than those in normal control group while SOD contentwas lower than that in normal control group. Pearson test showed that qEEG Fp1, Fp2, C3, C4,T3, T4, O1 and O2 loci power spectrum values in children with HIE were directly correlatedwith the contents of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes.Conclusion: The qEEG parameter values in children with HIE are lower than those in normalchildren, and the specific values are closely related to the severity of the disease.