Influence of folic acid and vitamin B12 combined therapy on plasma Hcy, inflammatory factor levels and blood vessels endothelial function in patients with vascular dementia and type H hypertension

摘要

Objective: To investigate influence of folic acid and vitamin B12 combined therapy on plasmahomocysteine (Hcy) level, blood vessels endothelial function and inflammatory factors inpatients with vascular dementia and type H hypertension. Methods: 100 cases of patients withvascular dementia and type H hypertension accorded with the inclusion criteria were selectedas research objects. They were randomly divided as the control group and the therapeuticgroup, 50 cases each. For control group, Enalapril tablets were administered by mouth fortreatment. For therapeutic group, folic acid and vitamin B12 treatment were provided on thebasis of treatment for control group. Treatments were continued for 12 weeks. Plasma Hcylevels, inflammatory factors [(interleukin-6 (IL-6), interleukin-8 (IL-8) and hypersensitive Creaction protein (hs-CRP)], blood vessels endothelial function indexes variation in patientsbefore and after treatment were observed and detected. Results: Plasma Hcy, IL-6, IL-8and hs-CRP levels in two groups of patients after treatment were significantly decreasedcomparing with the same group before treatment, and the above index levels in therapeuticgroup after treatment were significantly lower than control group (P0.05); After treatment, diastolic pressure and systolicpressure in the two groups of patients were significantly improved comparing with beforetreatment (P0.05). MMSE score in therapeutic groupafter treatment was significantly higher than before treatment, and significantly higher thanin control group (P0.05). Conclusions: Combined therapy of folic acid and vitamin B12 fortreating vascular dementia with type H hypertension could effectively decrease plasma Hcyand inflammatory factor levels, and improve blood vessels endothelial function and dementiadegree on patients. It has certain clinical value which deserves to be promoted.