Effect of Gongliuxiao Capsule on sex hormones, tumor markers, inflammatory factors and vascular endothelial function in patients with uterine fibroids

摘要

Objective: To investigate the effects of Gongliuxiao Capsule on inflammatory factors, tumormarkers, sex hormones and vascular endothelial function in patients with uterine fibroids.Methods: 130 patients with uterine fibroids admitted to our hospital from October 2015to March 2017 were enrolled. According to the treatment, they were divided into singletreatment group and combined medication group, with 65 cases in each group. The changesof inflammatory factors, tumor markers, sex hormones and vascular endothelial function werecompared before and after treatment in the two groups. Results: There were no significantdifferences in the levels of sex hormones, inflammatory factors, tumor markers and vascularendothelial function between the two groups (P0.05). The levels of sex hormones E2, P,FSH and LH, the levels of inflammatory factors TNF-α, MMP-9 and IGF-1, tumor markersCA125, CA19-9 and vascular endothelial function VEGF and b-FGF were significantlylower in the two groups (P0.05). The levels of E2, P, FSH and LH in the combined druggroups were (154.12±16.20) pmol/L, (9.12±1.02) μg/L, (13.84±1.42) U/L and (12.77±1.36)U/L, respectively，which were significantly lower than the single drug group level (P0.05).The levels of CA125 and CA19-9 in the combined drug group were (27.89±2.88) U/mLand (28.09±3.04) U/mL, respectively, which were significantly lower than the single druggroup (P0.05). The levels of TNF-α, MMP-9 and IGF-1 in the combined drug group were(24.16±2.63) ng/L, (159.22±16.82) μg/L and (69.75±7.09) μg/L, respectively, which weresignificantly lower than the single drug group(P0.05). The levels of VEGF and b-FGF in thecombination group were (138.29±14.32) μg/L and (98.59±10.02) μg/L, respectively, whichwere significantly lower than the single drug group (P0.05). Conclusion: Mifepristonecombined with Gongliuxiao Capsule can alleviate endocrine disorders, relieve inflammatorystress response and improve vascular endothelial function in patients with uterine fibroids. It isworthy of clinical application.