Correlation of Fibroscan parameter with serum inflammation indexes, collagen metabolism indexes and fibrosis indexes in patients with hepatitis b cirrhosis

摘要

Objective: To study the correlation of Fibroscan parameter with serum inflammation indexes, collagen metabolism indexes and fibrosis indexes in patients with hepatitis b cirrhosis. Methods: Patients who were diagnosed with hepatitis b cirrhosis in Dongfeng Hospital Affiliated to Hubei University of Medicine between June 2014 and August 2017 were selected as cirrhosis group for the research, patients who were diagnosed with chronic viral hepatitis b and without liver cirrhosis were selected as the HBV group, and healthy volunteers who received physical examination in Dongfeng Hospital Affiliated to Hubei University of Medicine during the same period were selected as the control group for the research; Fibroscan was performed to determine the liver stiffness measurement (LSM), and serum was collected to determine the inflammation indexes, collagen metabolism indexes and fibrosis indexes. Results: LSM levels as well as serum sICAM1, sP-selectin, MIF, MMP2, MMP9, CatS, TGFβ1, HA, LN, PC-III and IV-C contents of cirrhosis group and CHB group were significantly higher than those of control group whereas serum IL-21, IFN-γ, TIMP1 and TIMP2 contents were lower than those of control group; LSM level as well as serum sICAM1, sP-selectin, MIF, MMP2, MMP9, CatS, TGFβ 1, HA, LN, PC-III and IV-C contents of cirrhosis group was significantly higher than those of CHB group whereas serum IL-21, IFN-γ, TIMP1 and TIMP2 contents lower than those of CHB group; LSM level in cirrhosis group was positively correlated with serum sICAM1, sP-selectin, MIF, MMP2, MMP9, CatS, TGFβ1, HA, LN, PC-III and IV-C contents, and negatively correlated with serum IL-21, IFN-γ, TIMP1 and TIMP2 contents. Conclusion: The Fibroscan parameter LSM of hepatitis b cirrhosis has evaluation value for inflammatory response, collagen metabolism and fibrosis process in the course of cirrhosis.