Expression Level of Serum FGF-21 in Patients with Hypothyroidism and Correlation Analysis of Biochemical Indexes

摘要

Objective: To explore the expression level and correlation analysis of fibroblast growth factor 21 (FGF-21) and its biochemical indexes in serum of patients with hypothyroidism. Method: To collect 168 cases of patients in the Affiliated Hospital of Beihua University, 62 cases of hyperthyroidism group, 52 cases of hypothyroidism group, 54 cases of healthy group, which are adopted respectively by enzyme-linked immunosorbent assay (ELISA) detection of FGF-21; chemiluminescence detection of thyroid stimulating hormone (TSH), serum free triiodothyronine (FT3), free thyroxine (FT4); detection of, biochemical analyzer of total cholesterol (TC) and triglyceride (TG), low density lipoprotein (LDL), as well as high density lipoprotein (HDL) and other indicators. Results: ① The amount of FGF-21, TSH, TC, TG and LDL of serum in hypothyroidism group is significantly higher than that in control group (P<0.05), the amount of FT3, FT4 and HDL of serum in free thyroxine is significantly lower than that in control group (P<0.05). The amount of FGF-21, TSH, TC, TG and LDL of serum in hyperthyroidism group is significantly lower than that in control group (P<0.05), the amount of FT3, FT4 and HDL of serum in free thyroxine is significantly higher than that in control group (P<0.05); ②Through the correlation analysis between plasma FGF-21, the level of plasma FGF-21 in patient with hypothyroidism is positively correlated with age, gender, TSH, TC, LDL. Conclusion: The level of serum FGF-21 is increased in hypothyroidism patients, which is correlated with TSH, TC, TG and LDL, etc. which may be the risk factors for thyroid dysfunction and result in the development of disease. The elevation of TC, TG and LDL in patients with hypothyroidism may also be one of the main causes of dyslipidemia.