Evaluation of Platelet Rich Fibrin in the Management of Gingival Recession Type I/II by Miller: A Randomized Clinical Split Mouth Study

摘要

Introduction: The ultimate goal of mucogingival plastic surgery is to obtain complete root coverage and an optimal appearance. The aim of this study was to evaluate the efficacy of platelet-rich fibrin (PRF) with coronally advanced flap (CAF) compared to connective tissue graft (CTG) with CAF in the treatment of gingival recession (GR). Material and Methods: A total of 20 patients were included in this randomized clinical study, presenting 40 GR Miller type I/II. The GR sides of patients were assigned randomly into test group (PRF?+?CAF) and control group (CTG?+?CAF). Clinical parameters, such as GR, probing depth (PD), clinical attachment level (CAL), and width of keratinized gingiva (WKG), were evaluated at baseline and 12 months later. Root coverage (RC %) and complete root coverage (CRC %) were assessed at 12 months post surgically. Statistical analysis was performed using paired, independent t-test and Mann–Whitney U test. Statistical significance was set at 0.05. Results: At 12 months the mean (SD) GR was 0.20?±?0.50?mm for test group and 0.05?±?0.15?mm for control group, whereas the mean RC% was 95.32?±?11.92 for PRF?+?CAF and 98.61?±?4.37 for CTG?+?CAF. CRC was obtained in CTG?+?CAF with 90% and with 80% in PRF?+?CAF. CAL gain was 2.80?±?0.28?mm and 2.49?±?0.55?mm in test and control sites, respectively. The gain of WKG was 1.31?±?0.45?mm and 1.85?±?0.25?mm in test and control sites, respectively. All the values were not significantly different (P ≥ 0.05). Conclusion: Using of PRF?+?CAF in the treatment of GR is a successful and effective treatment option and could serve as an alternative to CTGs.