Triterpenes with 5-Lipoxigenase (5-LOX) and Xanthine Oxidase (XOD) Inhibitory Activity from the Stem of Ficus Aurantiaca Griff

摘要

Two compounds identified as taraxerone 1 and taraxerol 2 have been isolated from Ficus aurantiaca. There has been no previous report on the chemical constituents and biological activities of this plant. Compounds 1 and 2 were isolated from EAextract of the stem of F. aurantiaca. The structures were evaluated based on spectroscopic methods including nuclear magneticresonance (NMR), UV, IR and mass spectrometry and comparison with the published information in the literature. The 5-lipoxenase enzyme inhibition assay showed that compound 1 and 2 have 5-LOX inhibitory activity with IC50 of 21.67 ± 6.52 (μg/mL) and 23.07 ± 7.30 (μg/mL) respectively. On the other hand compound 1 and 2 exhibited significant XOD inhibitory activity with IC50 of 8.72±1.79 (μg/mL) and 12.87±5.10 (μg/mL) respectively.