Investigation of the Relationship between Breast Cancers ?and HPVs

摘要

High-risk human papillomaviruses (HR-HPVs) ?have been implicated in ?the aetiology of a variety of human ?cancers, including cervical, colorectal, and head and ?neck ??(HN); also, (HPVs) may be important risk factors for breast ?carcinogenesis and ?metastasis. Previous studies that ?evaluated the prevalence of HPVs in breast cancer ?have ?generated considerable controversy. Based on this ?hypothesis, we aimed to investigate ?the prevalence of HPV ?infection in invasive breast cancer tissues. ?Our study included 80 paraffin ?blocks taken from breast ?cancerous tissue specimens of ?Turkish female patients and 13 controls (cervical ?cancerous ?tissue specimens) in Research and Practice Hospital- ?Sahinbey -Gaziantep ?University, using PCR (HPV Genotypes ??14 Real-TM Quant / Italy) to detect the HR-?HPV DNA. ?In our results: HR-HPV DNA was evidenced in (10%) of the breast ?cancer and in (92.3%) of ?the controls (p < 0.05). HPV (45-56-68) were the most prevalent genotypes in ?breast ?cancer cases. Also HPV co-infection was high (75%) in ?positive breast cancerous ?samples.? Our data propose Human papilloma viruses ?may play a role as a possible ?causal relationship, or ?mediation or even as a cofactor in the development of some ?types ?of breast cancer, this still needs to be confirmed by prospective studies.