Stilbene analogues as inhibitors of breast cancer Stem cells through P-glycoprotein efflux; A 3D quantitative structure-activity relationship study (Inhibitory activity of stilbenes analogues on breast cancer stem cells)

摘要

Some stilbene analogues are essentially important for inhibiting the expression of P-glycoprotein in cancer stem cells. P-glycoprotein is a ATP binding cassette (ABC) transporter that mediates efflux process through ATP hydrolysis. This protein is composed of nucleotide binding and transmembrane domains. The expression level of P-glycoprotein is reported to be high in the cancer stem cell population. Stilbenes are phenylpropanoid-derived naturally occurring secondary metabolites of plants, reported as third generation inhibitors of P-glycoprotein. Based on biological activities of stilbenes against breast cancer cell line, the 3D quantitative structure-activity relationship and docking simulation study was carried out to predict the pharmacophoric features of these compounds. This study is likely to enable researchers to design and synthesize novel therapeutic analogues for reducing the growth of breast cancer stem cells by inhibiting the expression level of P-glycoprotein.