Stevens Johnson Syndrome—Toxic Epidermal Necrolysis Induced by A Combination of Lamotrigine and Valproic Acid: A Case Report

摘要

Both Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and life-threatening acute allergic reactions affecting the skin and mucous membranes. We report a case with SJS-TEN likely induced by inappropriate lamotrigine titration during the use of a lamotrigine and valproic acid regimen. The present case report supports the clinical evidence that combination of lamotrigine with other psychiatric drugs increases the frequency and severity of skin reactions. Therefore in polypharmacy, lamotrigine should be used more carefully and lamotrigine should be discontinued if any rash appears.?ZETStevens-Johnson sendromu (SJS) ve toksik epidermal nek-roliz (TEN) deri ve mukozay? etkileyen, nadir olarak g?rülen ve hayat? tehdit eden akut allerjik reaksiyonlard?r. Bu yaz?da lamotrijin ve valproik asit kullanan hastada, lamotrijin titrasyonun uygunsuz olmas? sonucu geli?en SJS-TEN vakas? bildirilmi?tir. Bu vaka, lamotrijin ile birlikte di?er psikiyatrik ila?lar?n kullan?m? sonucunda, daha s?k ve daha ciddi cilt reaksiyonlar?n?n olu?abilece?ini vurgulamaktad?r. Bu nedenle lamotrijin kullan?rken ?oklu psikiyatrik ila? kullan?m?ndan ka??nmal?, herhangi bir cilt reaksiyonu g?rülmesi halinde lamotrijin kesilmelidir.