Lu-177-PSMA-617 Prostate-Specific Membrane Antigen Inhibitor Therapy in Patients with Castration-Resistant Prostate Cancer: Stability, Bio-distribution and Dosimetry

Levent Kabasakal; Türkay Toklu; Nami Yeyin; Emre Demirci; Mohammad Abuqbeitah; Meltem Ocak; Aslan Aygün; Emre Karayel; Hüseyin Pehlivano?lu; Nalan Alan Sel?uk

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Lu-177-PSMA-617 Prostate-Specific Membrane Antigen Inhibitor Therapy in Patients with Castration-Resistant Prostate Cancer: Stability, Bio-distribution and Dosimetry

机译：Lu-177-PSMA-617对去势抵抗性前列腺癌患者的前列腺特异性膜抗原抑制剂治疗：稳定性，生物分布和剂量学

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Objective:The aim of the study was to estimate the radiation-absorbed doses and to study the in vivo and in vitro stability as well as pharmacokinetic characteristics of lutetium-177 (Lu-177) prostate-specific membrane antigen (PSMA)-617.

机译：目的：研究目的是评估of 177（Lu-177）前列腺特异膜抗原（PSMA）-617的辐射吸收剂量，并研究其体内和体外稳定性以及药代动力学特性。

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《Molecular Imaging Radionuclide Therapy》 |2017年第2期|共页
作者
Levent Kabasakal; Türkay Toklu; Nami Yeyin; Emre Demirci; Mohammad Abuqbeitah; Meltem Ocak; Aslan Aygün; Emre Karayel; Hüseyin Pehlivano?lu; Nalan Alan Sel?uk;
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中图分类放射卫生;
关键词
PSMAprostate-specific membrane antigenLu-177-PSMAprostate cancercastration-resistant prostate cancerradionuclide therapy;

机译：PSMA前列腺特异性膜抗原Lu-177-PSMA前列腺癌耐cast割的前列腺癌放射性核素治疗;

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专利

1. Pre-therapeutic dosimetry of normal organs and tissues of Lu-177-PSMA-617 prostate-specific membrane antigen (PSMA) inhibitor in patients with castration-resistant prostate cancer [J] . Kabasakal Levent, AbuQbeitah Mohammad, Aygun Aslan, European Journal of Nuclear Medicine and Molecular Imaging . 2015,第13期

机译：Lu-177-PSMA-617前列腺特异性膜抗原（PSMA）抑制剂对去势抵抗性前列腺癌患者的正常器官和组织的治疗前剂量
2. Pre-therapeutic dosimetry of normal organs and tissues of 177Lu-PSMA-617 prostate-specific membrane antigen (PSMA) inhibitor in patients with castration-resistant prostate cancer [J] . Levent Kabasakal, Mohammad AbuQbeitah, Aslan Aygün, European Journal of Nuclear Medicine and Molecular Imaging . 2015,第13期

机译：177Lu-PSMA-617前列腺特异膜抗原（PSMA）抑制剂对去势抵抗性前列腺癌患者的正常器官和组织的治疗前剂量
3. 340?Phase 1 study of AMG 160, a half-life extended BiTE? (bispecific T-cell engager) therapy targeting prostate-specific membrane antigen, in patients with metastatic castration-resistant prostate cancer [J] . Tanya Dorff, Matthew Rettig, Jean-Pascal Machiels, Journal for ImmunoTherapy of Cancer . 2020,第Suppla3期

机译：340？相1研究AMG 160，半衰期延伸咬合？（双特异性T细胞录音机）靶向前列腺特异性膜抗原的治疗，抗转移性阉割的前列腺癌患者
4. Analysis of glycoforms of urinary prostate-specific antigen of prostate cancer and benign prostate hyperplasia samples [C] . Chun-Jen Hsiao, Tzong-Shin Tzai, Chein-Hung Chen, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：前列腺癌和良性前列腺增生样品的尿道前列腺特异性抗原糖族分析
5. Studies on human prostate-specific antigen as a tumor antigen for the immunotherapy of prostate cancer in a mouse model. [D] . Willis, Richard Allen. 2002

机译：人类前列腺特异性抗原作为一种肿瘤抗原的免疫模型在小鼠模型中的研究。
6. Lu-177-PSMA-617 Prostate-Specific Membrane Antigen Inhibitor Therapy in Patients with Castration-Resistant Prostate Cancer: Stability Bio-distribution and Dosimetry [O] . Levent Kabasakal, Türkay Toklu, Nami Yeyin, 2017

机译：Lu-177-PSMA-617对去势抵抗性前列腺癌患者的前列腺特异性膜抗原抑制剂治疗：稳定性生物分布和剂量学
7. Lu-177-PSMA-617 Prostate-Specific Membrane Antigen Inhibitor Therapy in Patients with Castration-Resistant Prostate Cancer: Stability, Bio-distribution and Dosimetry [O] . Levent Kabasakal, Türkay Toklu, Nami Yeyin, 2017

机译：Lu-177-psma-617前列腺特异性膜抗原抑制剂治疗去势抵抗性前列腺癌患者：稳定性，生物分布和剂量学

Lu-177-PSMA-617 Prostate-Specific Membrane Antigen Inhibitor Therapy in Patients with Castration-Resistant Prostate Cancer: Stability, Bio-distribution and Dosimetry

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