RELATION BETWEEN THYROID HORMONE CONCENTRATION AND SERUM LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-10 IN PATIENTS WITH NONTHYROIDAL ILLNESS INCLUDING CHRONIC KIDNEY DISEASE

摘要

Introduction: We evaluated relations between interleukins (IL) IL-6 and IL-10 and euthyroid sick syndrome (ESS) in patients with nonthyroidal illness (NTI). Materials and Methods: Sixty patients and 20 healthy volunteers were recruited. The patients had either chronic kidney disease (CKD), congestive heart failure (CHF), or acute myocardial infarction (MI), distributed equally in 3 subgroups. Serum levels of IL-6 and IL-10, thyroid stimulating hormone (TSH), total T4, and T3 were determined. Results: In the 60 patients with NTI, we detected a significantly lower T3 and T4 levels compared to controls, while TSH level was within the reference range. Also, IL-6 level was substantially higher than that in controls (P Conclusions: The high frequency of ESS in patients with NTI may be linked to IL-6 and IL-10 alterations. Perturbation of IL-6, and not IL-10, might be involved in the pathogenesis of ESS along with other key players as suggested by our findings in CKD.