Oral controlled release dosage forms have been developed over the past three decades due to their considerable therapeutic advantages such as ease of administration patient compliance and flexibility in formulation. Throughout the gastrointestinal tract, these considerations have led to the development of a unique oral controlled release dosage form with Gastro retentive properties. Gastro retentive dosage forms (GRDFs) can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility of drugs that are less soluble in a high pH environment. There are different types of gastro retentive dosage forms the formulation of floating microspheres is solvent diffusion evaporation technique. Acebutolol is commonly prescribed as angiotensin drug. Gastric retention time is increased because of buoyancy and site-specific delivery in stomach can be achieved. Pre formulation studies have done to formulate the floating microspheres, Acebutolol as API and three polymers were used namely Cellulose Acetate (F1), EdurgitS100 (F2), Acrycoat S100 (F3). For the above formulations all the evaluation parameters (SEM studies, buoyancy studies, the in vitro studies, Floating time) were conducted. The microspheres were placed in 6.8 pH phosphate buffer containing surfactant tween 80 to stimulate gastric condition. The drug release from floating microspheres found to be 84.22 ±0.29, 75.19 ±1.99, 67.59 ±1.97for F1, F2, and F3 respectively.
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