Effect of Edaravone on Postoperative Cognitive Function and Cerebral Oxygen Metabolism in Elderly Patients with Spinal Surgery

摘要

Background: To investigate the effect of edaravone on the postoperative cognitive function and cerebral oxygen metabolism in elderly patients with spinal surgery. Methods: One hundred and twenty patients undergoing elective thoracolumbar surgery, aged 65-75 years, were randomly divided into two groups: edaravone group (Group E, n=60) and control group (Group C, n=60). At 30 minutes before anesthesia, the patients in Group E received 0.5 mg/kg edaravone, while the patients in Group C received the same volume of normal saline. Mini-mental state examination (MMSE) was performed at 1 day before the operation, and 1 day and 4 days after the operation. Results: A total of 26 patients in both groups had postoperative cognitive dysfunction. Compared with the preoperative MMSE scores, postoperative MMSE scores decreased significantly in both groups (p<0.05) and the reduction in the 1-day postoperative MMSE scores in Group E was remarkably lower than that in Group C (p<0.05). Conclusion: Edaravone can reduce the incidence of early postoperative cognitive dysfunction in elderly patients. The underlying mechanism may be related to improvement of cerebral oxygen metabolism.