Preclinical, Pharmacological and Toxicological studies of Karpoora Chindhamani Mathirai (KCM) for Analgesic, Anti-inflammatory, Anti-pyretic effects in rats

摘要

Siddha system of medicine is indigenous to India. The drug Karpoora Chindhamani Mathirai chosen from classic Siddha text is subjected to preclinical toxicity studies and for analgesic, anti-inflammatory and antipyretic effects in rats. These preclinical studies are performed to bring a strong evidence based support on the traditional medicine. Toxicity studies are performed as per OECD guidelines and Karpoora Chindhamani Mathirai at the dose of 2000 mg/kg/po did not exhibit any mortality in rats. Karpoora Chindhamani Mathirai exhibited significant anti inflammatory activity in both carrageenin induced hind paw and cotton pellet granuloma model in rats. The results are comparable to Diclofenac sodium (5gm/ kg/po). Karpoora Chindhamani Mathirai also exhibited significant antipyretic and analgesic activity.