Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control Study

摘要

Objective: Gallbladder cancer is the commonest gastrointestinal cancer in northern Indian women. Some studieshave examined the association between Helicobacter pylori infection and gallbladder cancer risk, but findings have beeninconsistent. We aimed to examine the association between H. pylori infection and gallbladder cancer in Indian people.Materials and Methods: We conducted a hospital-based case-control study including 100 gallbladder cancer patientswith gallstones who were 32 to 79 years old (cases; 72 women and 28 men), and 100 cholelithiasis patients aged 14 to75 years (controls; 65 women and 35 men). All patients had a diagnosis of gallbladder cancer or cholelithiasis at theSanjay Gandhi Post Graduate Institute of Medical Sciences in Lucknow having a high gallbladder cancer incidencein northern India, from May 2014 through July 2017. Plasma samples were collected from all patients before surgicaltreatment. Plasma H. pylori antibody titer was measured by the latex agglutination method and an autoanalyzer. H.pylori infection was defined as antibody titer ≥10 U/mL. Plasma antibody titers and H. pylori infection positivity rateswere compared between cases and controls. Results: Mean plasma antibody titers (standard deviation, range) were11.1 U/mL (11.6, 0–78) in cases and 13.6 U/mL (23.0, 1–164) in controls. H. pylori infection positivity rates were41% and 42% in cases and controls, respectively. No significant differences in antibody titers or H. pylori infectionpositivity rates were found between cases and controls. Conclusions: We found no evidence of H. pylori infection asan important risk factor for gallbladder cancer in Indian people.