Association of SOD2 gene polymorphism with noise induced hearing loss in textile industry employees

摘要

Noise exposure leads to hearing loss in industrial workers due to release of superoxide anions which damage cochlear epithelium in the ear. These free radicals are regulated bysuperoxide dismutase 2 (SOD2)and polymorphism in this gene may abet in predisposition tonoise induced hearing loss (NIHL). The current study describes prevalence of polymorphism at two different loci ofSOD2genein NIHL patients and association of smoking habit with NIHL. PCR-SSCP analysis of polymorphic sites revealed mutation in NIHL patients. Results showed thatIVS1+8A/G andIVS3-23T/GSOD2 polymorphisms are associated with NIHL (p 0.05, CI 95%) irrespective of smoking habit (p 0.01). It is intended thatSOD2polymorphism plays a significant diagnostic role in determining susceptibility of NIHL in Pakistani industry employees.