Neuromodulation for chronic urologic pain

摘要

Chronic urologic pain, be it bladder pain syndrome, prostatitis,or some other form of urologic chronic pelvic painsyndrome (UCPPS), may present in a variety of symptomsand severities. A multimodal approach, as outlined in thissupplement, is generally required to manage these difficultto-treat conditions. One option available may be to electricallyalter the afferent pain signals within the pelvis throughsacral neuromodulation (SNM). The bladder and pelvic floorare innervated via sacral nerve roots, which transmit afferentsensory signals up to the brain. The S3 sacral nerve rootis most specifically associated with sensory function of thedetrusor and pelvic floor muscles. In addition to afferentsensory and efferent motor nerves responsible for bladderand bowel function, pain signals are transmitted throughC-fibres and Aδ-fibers that travel along the same path.