NGAL expression during cardiopulmonary bypass does not predict severity of postoperative acute kidney injury

摘要

Background Renal injury is a serious complication after cardiac surgery and therefore, early detection and much more prediction of postoperative kidney injury is desirable. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictive biomarker of acute kidney injury and may increase after cardiopulmonary bypass (CPB). However, time correlation of NGAL expression and severity of renal injury is still unclear. The aim of our study was to investigate CPB-related urine NGAL (uNGAL) secretion in correlation to postoperative renal function. Methods Data of NGAL expression along with clinical data of 81 patients (52 male and 29 female) were included in this study. Mean age of the patients was 66.8?±?12.8?years. Urine NGAL was measured at seven time points (T₀: baseline; T₁: start CPB, T₂: 40?min on CPB; T₃: 80?min on CPB; T₄: 120?min on CPB; T_p1: 15?min after CPB; T_p2: 4?h after admission to the intensive care unit) and renal function in the postoperative period was classified daily according to Acute Kidney Injury Network (Ronco et al, Int J Artif Organs 30(5): 373–6) criteria (AKIN). Results Expression of uNGAL increased at T₄ (120?min on CPB) and post-CPB (T_p1 and T_p2; p Conclusion Although uNGAL expression increased after CPB, the peak values neither predict acute postoperative kidney injury, nor severity of the injury.