Application of chemistry to in vitro diagnostic tests

摘要

Diagnostic testing for the screening, diagnosis and manage- ment of disease involves the detection and quantitation of a vide range of molecules, structures or whole cells in a complex biological matrix. Whilst separation techniques linked to physicochemical detection may be employed in the early investigation of a new marker, invariably the transi- tion to routine application depends on the use of a biorecognition molecule, typically an enzyme or an anti- body. In recent years the application of synthetic chemistry has led to the demonstration of synthetic biorecognition molecules-the search for specificity being aided by ad- vances in combinatorial chemistry.