Gold(I) complex of N,N'-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition ofthioredoxin reductase

摘要

Coinage metal complexes of an N,N-disubstituted cyclic thiourea exert significant cytotoxicities to cancer cells and, in particular, the gold(I) thiourea complex exhibits a potent tight-binding inhibition of the anticancer drug target thioredoxin reductase with an inhibitory constant at nanomolar level.