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首页> 外文期刊>Chemical Communications >Recognition of forcible curvature in circular DNA by human topoisomerase I
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Recognition of forcible curvature in circular DNA by human topoisomerase I

机译：人类拓扑异构酶I识别环状DNA中的强制弯曲

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摘要

A series of forcible curved circular DNAs (cDNAs) were prepared to investigate the recognition features of human Topoisomerase I (hTopo I). The IC50 can be modulated by the curvature degrees of cDNA. In addition, preferential bindings of hTopo I to cDNA with high curvature have been observed by AFM and EMSA.
机译：制备了一系列强制弯曲的圆形DNA（cDNA），以研究人拓扑异构酶I（hTopo I）的识别特征。可以通过cDNA的弯曲度来调节IC50。另外，通过AFM和EMSA已经观察到hTopo I与高曲率的cDNA的优先结合。

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  • 来源
    《Chemical Communications》 |2011年第40期|p.11309-11311|共3页
  • 作者

    Zhaoqi Yang; Dawei Li; Shuhui Hiew; Magdeline Taotao Ng; Weixing Yuan; Haibin Su; Fangwei Shao; Tianhu Li;

  • 作者单位

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University,21 Nanyang Link, Singapore 637371, Singapore.;

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