Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma

摘要

CONCLUSION: The high expression level of hTcf-4 in HCC, especially in tumors with metastasis, suggests that the over- expression of hTcf-4 gene may be closely associated with development and progression of HCC, but the mutation of this gene seemed to play less important role in this respect. AIM: Hepatocellular carcinoma(HCC) is a significant health problem in China. But the molecular mechanisms of HCC remains unclear. APC/β-Catenin/Tcf signaling pathway, also known as Writ pathway, plays a critical role in the development and oncogenesis. As little is known about the alteration of human T-cell transcription factor-4 (hTcf-4) gene in HCC, it is of interest to study the expression and mutation of hTcf-4 gene in HCC and the relationship between hTcf-4 gene and progression of HCC.