Effect of L-NAME on nitric oxide and gastrointestinal motility alterations in cirrhotic rats

摘要

Conclusion: Gastrointestinal motility was remarkably inhibited in cirrhotic rats, which could be alleviated by L- NAME. Nitric oxide may play an important role in the Inhibition of gastrointestinal motility in cirrhotic rats. Aim: To investigate the effect of L-NAME on nitric oxide and Gastrointestinal motility alterations in cirrhotic rats. Methods: Rats with cirrhosis induced by carbon Tetrachloride were randomly divided into two groups, one(n =13)receiving 0.5 mg.kg~-1 per day of N~G-nitro-L-arginine methyl ester(L-NAME), a nitric oxide synthase inhibitor, for 10 days, whereas the other group(n = 13)and control (n = 10)rats were administrated the same volume of 6 g.L~-1 saline.