Functional and pathological characteristics of reversible remodeling in a canine right ventricle in response to volume overloading and volume unloading

摘要

PurposesPatients who undergo right ventricular (RV) outflow augmentation inevitably develop RV remodeling due to pulmonary insufficiency-related volume overload (VOL). However, the reversibility of this remodeling is not fully understood. The goal of this study was to establish an animal model of VOL and unloading to characterize the functional and pathological characteristics and reversibility of RV remodeling.