MDL28170 a Calpain Inhibitor Affects Trypanosoma cruzi Metacyclogenesis Ultrastructure and Attachment to Rhodnius prolixus Midgut

摘要

Background Trypanosoma cruzi is the etiological agent of Chagas' disease. During the parasite life cycle, many molecules are involved in the differentiation process and infectivity. Peptidases are relevant for crucial steps of T. cruzi life cycle; as such, it is conceivable that they may participate in the metacyclogenesis and interaction with the invertebrate host.