Comparisons of in vitro Fick’s first law lipolysis and in vivo rat models for oral absorption on BCS II drugs in SNEDDS

摘要

PurposeThe objective of this study was to compare the in vitro Fick’s first law, in vitro lipolysis, and in vivo rat assays for oral absorption of Biopharmaceutical Classification Systems Class II (BCS II) drugs in self-nanoemulsifying drug delivery system (SNEDDS), and studied drugs and oils properties effects on the absorption.