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Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors

机译:纳米技术创新在实体瘤检测和治疗中的作用概述

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摘要

Nanotechnology, although still in its infantile stages, has the potential to revolutionize the diagnosis, treatment, and monitoring of disease progression and success of therapy for numerous diseases and conditions, not least of which is cancer. As it is a leading cause of mortality worldwide, early cancer detection, as well as safe and efficacious therapeutic intervention, will be indispensable in improving the prognosis related to cancers and overall survival rate, as well as health-related quality of life of patients diagnosed with cancer. The development of a relatively new field of nanomedicine, which combines various domains and technologies including nanotechnology, medicine, biology, pharmacology, mathematics, physics, and chemistry, has yielded different approaches to addressing these challenges. Of particular relevance in cancer, nanosystems have shown appreciable success in the realm of diagnosis and treatment. Characteristics attributable to these systems on account of the nanoscale size range allow for individualization of therapy, passive targeting, the attachment of targeting moieties for more specific targeting, minimally invasive procedures, and real-time imaging and monitoring of in vivo processes. Furthermore, incorporation into nanosystems may have the potential to reintroduce into clinical practice drugs that are no longer used because of various shortfalls, as well as aid in the registration of new, potent drugs with suboptimal pharmacokinetic profiles. Research into the development of nanosystems for cancer diagnosis and therapy is thus a rapidly emerging and viable field of study.
机译:纳米技术虽然仍处于婴儿期,但它有可能彻底改变疾病进展的诊断,治疗和监测方法,并成功治疗多种疾病和病症,尤其是癌症。由于它是全球死亡的主要原因,因此,早期癌症检测以及安全有效的治疗干预将是改善与癌症和总体生存率以及所诊断患者的健康相关生活质量有关的预后必不可少的与癌症。相对较新的纳米医学领域的发展,结合了包括纳米技术,医学,生物学,药理学,数学,物理学和化学在内的各种领域和技术,已经产生了应对这些挑战的不同方法。与癌症特别相关的是,纳米系统在诊断和治疗领域已显示出可观的成功。归因于纳米级尺寸范围的归因于这些系统的特征允许治疗的个体化,被动靶向,针对更特异性靶向的靶向部分的附着,微创程序以及体内过程的实时成像和监测。此外,掺入纳米系统可能具有将因各种不足而不再使用的药物重新引入临床实践的潜力,并有助于注册具有次优药代动力学特征的新型有效药物。因此,对用于癌症诊断和治疗的纳米系统的开发研究是一个迅速兴起且可行的研究领域。

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