Dehydrative Transformation of Spirooxindoles to Pyrido23-bindoles via POCl3

摘要

A two-step one-pot efficient synthesis of pyrido[2,3-b]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI or methanol results in spirooxindoles that undergo POCl3-mediated intramolecular dehydrative transformation to afford the title compounds.