Association of Methylentetraydrofolate Reductase (MTHFR) 677 C T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study

摘要

BackgroundThe methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels.