Early L-T4 intervention improves fetal heart development in pregnant rats with subclinical hypothyroidism rats by activating BMP4/Smad4 signaling pathway

摘要

Effects of L-T4 treatment on the expression levels of serum TSH and TT4 in the offspring of SCH pregnant rats. a TSH expression level of pregnant rats in the Sham, SCH, LT4-E10 (L-T4 treatment started on the 10th day of gestation), and LT4-E13 (L-T4 treatment started on the 13th day of gestation) groups. There were 20 rats in each group. b TT4 expression level of pregnant rats in each group. *p < 0.05 vs Sham group; #p < 0.05 vs SCH group