Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain

摘要

The AD brain has increased amounts of insoluble proteins. Amido black stained Western blot of control and AD cortex RIPA-insoluble fractions (aggregates). Each lane is a cortical sample from one individual, presented in the same order as the cases in Table S1 (1–16). The ratios reflecting the total protein in the various quadrants are presented along with tubulin. The 51 kDa protein (tubulin) was excluded from the analysis of each quadrant. P values are given. Data are presented as mean ± SEM (n = 8/group)